Stacy Malaker, Assistant Professor, Department of Chemistry, Yale University, will give a talk on "Mucinomics as the next frontier of mass spectrometry."

This seminar will also be available by Zoom. Zoom link: https://gc-cuny.zoom.us/j/91032629703. Meeting ID: 910 3262 9703. Passcode: ASRC+CCNY

ABSTRACT

Mucin-domain glycoproteins are densely O-glycosylated and play key roles in a host of biological functions. However,
their dense O-glycosylation remains enigmatic both in glycoproteomic landscape and structural dynamics, primarily due to the challenges associated with studying mucin domains. Here, we present advances in the mass spectrometric analysis of mucins, including the characterization of mucinases, enrichment techniques, and complete mucinomic mapping of translationally relevant mucin proteins.