This seminar will only be available remotely via Zoom.
VIEW THIS SEMINAR LIVE VIA THE WEB AT:
https://zoom.us/j/449901184

Robert B. Best, Senior Investigator, Theoretical Biophysical Chemistry Section, Laboratory of Chemical Physics, NIDDK, National Institutes of Health, will give a talk on "Structure and dynamics of intrinsically disordered proteins, their complexes and assemblies"

ABSTRACT

Intrinsically disordered proteins are now realized to play a variety of important biological roles, yet pose a challenge for experiments, because observed signals are averaged over a very heterogeneous ensemble of structures. Molecular simulations can help to interpret the results, if appropriately parameterized to match experimental data. I will describe our work using both atomistic and coarse-grained simulations to model the structure and dynamics of disordered proteins, and their disordered complexes and assemblies, especially those involving highly charged biomolecules. These include the role of a protein chaperone in the folding of nucleic acids, and the formation of coacervates at lower ionic strength and higher protein concentrations.