Kim Orth, Professor of Molecular Biology and Biochemistry at University of Texas Southwestern in Dallas, TX, will give a talk titled, "Black Spot, Black Death, Black Pearl: The Tales of Bacterial Pathogens."

This seminar will also be available by Zoom. Zoom link: https://gc-cuny.zoom.us/j/91448257859?pwd=2dSdb1Ne4u1liuzauChpsX5m6Ya5L…; Meeting ID: 914 4825 7859.  Passcode:  asrc+ccny

ABSTRACT

My lab is interested in elucidating the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems. One of these factors encodes a Fic domain that exhibits diverse activity depending on the species using this enzyme. In metazoans the Fic domain is used for AMPylation to maintain homeostasis in cells when under stress.  Recently, we developed a pre-clinical model of dysregulated FicD AMPylation that causes infant onset diabetes.