James Prestegard, Emeritus Professor, Dept. of Chemistry and Dept. of Biochemistry & Molecular Biology, University of Georgia, will give a talk titled "NMR in the age of AI; What can it tell us about glycans and glycoproteins?"

ABSTRACT

Artificial Intelligence (AI) has had an impact on structural biology, both by providing structures of proteins that allow us to focus more on their functional properties and by providing tools that allow us to analyze data more efficiently. I will present two examples from our NMR investigation of glycans and glycoproteins; one applying new resonance assignment strategies for the sparsely isotope labeled glycoprotein, CEACAM1, and one applying a neural net analysis to ring conformations of a monosaccharide found in heparin. Both provide insight into properties of molecules that impact our health, but they also provide an opportunity to learn about the potential and limitations of some exciting new tools for structural biology.

Zoom link: https://gc-cuny.zoom.us/j/96677631144. Meeting ID:  966 776 31144. Passcode: asrc-ccny