Jack Zhang, Assistant Professor of Molecular Biophysics and Biochemistry, Yale University School of Medicine, will give a talk on "High-resolution in situ Structures within Mitochondria."

This seminar will also be available by Zoom. Zoom link: https://gc-cuny.zoom.us/j/91448257859?pwd=2dSdb1Ne4u1liuzauChpsX5m6Ya5L…; Meeting ID: 914 4825 7859.  Passcode:  asrc+ccny

ABSTRACT

Mitochondria are essential for ATP production via oxidative phosphorylation, involving respiratory complexes within the inner membrane. Despite extensive in vitro studies, understanding their mechanisms in physiological environment is challenging due to loss of the native environment during purification. Here, we directly image porcine mitochondria by developing a high-resolution in-situ cryo-electron microscopy technique, which enabled us to determine near-atomic structures of various respiratory supercomplexes in the native membrane.