Andrei A. Korostelev, Professor, RNA Therapeutics Institute University of Massachusetts Chan Medical School, will give a talk on "The ribosome in action: uncovering translation and new stress sensing mechanisms by cryo-EM."

ABSRACT

Ribosomes are a central hub for controlling gene expression. Not only do they synthesize proteins, but they potently respond to stress signals. Our lab addresses mechanistic questions concerning ribosome functions, such as: How does the ribosome accurately synthesize proteins? How does the ribosome sense cellular stresses? In my presentation, I will talk about our use of time-resolved cryo-EM and biochemistry to visualize how the ribosome accurately reads the genetic instructions encoded in mRNA and how stalled ribosomes can initiate profound changes in cellular pathways in response to stress.