Jun Yoshioka
Medical Professor
Additional Departments/Affiliated Programs
Molecular, Cellular and Biomedical Sciences
Building
Harris Hall
Office
H-205-M
Phone
212-650-7876
Jun Yoshioka
Profile
Dr. Jun Yoshioka is Professor of the Department of Molecular Cellular & Biomedical Sciences at CUNY School of Medicine. After completed his initial medical training, he started clinical research work in Japan. He then shifted his focus to basic research in physiology and molecular biology in 2001, starting a post-doctoral fellowship at Brigham and Women’s Hospital and Harvard Medical School. Dr. Yoshioka spent the majority of his career as a research scientist at Harvard Medical School where he served as an Assistant Professor of Medicine before coming to CUNY in 2017. His background in clinical cardiology combined with the expertise he has gained in the basic laboratory have allowed him to contribute fundamental insights into normal cardiac physiology and its dysregulation in the setting of metabolic disorders. Dr. Yoshioka is honored to be an Alan Lerner Award recipient in 2015 and a Watkins Discovery Award winner in 2016 at Brigham and Women’s Hospital.
Education
Ph.D., 2001. Osaka University Graduate School of Medicine (Japan)
M.D., 1994. Hyogo College of Medicine (Japan)
Research Interests
Dr. Yoshioka’ career has been dedicated to understanding disorders of cardiac function with the goal of developing novel therapies based upon fundamental insights into cellular and physiological mechanisms. He has been supervising innovative and meritorious research projects on cardiac metabolism and discovered that a previously obscure protein called TXNIP (“tex-nip”) controls mitochondrial redox balance and cellular glucose transport. His laboratory's current work focuses on diabetic cardiomyopathy, which is caused by diabetic stress’s effects on the cardiac system. Using modified mouse models that lacked the TXNIP gene, his group created a model of diabetes and found that the TXNIP-deficient mice had significantly better outcomes than the wild-type mice, including more stable blood sugar levels and fewer early signs of heart disease. He plans to continue expanding his investigations and examine the role TXNIP in other oxidative stress-related illnesses.
Publications
Nakayama Y, Mukai N, Kreitzer G, Patwari P, Yoshioka J. Interaction of ARRDC4 with GLUT1 Mediates Metabolic Stress in the Ischemic Heart. Circ Res 2022 Sep 2;131(6):510-527
Mukai N*, Nakayama Y*, Abdali SA, Yoshioka J. Cardiomyocyte-specific Txnip C247S mutation improves left ventricular functional reserve in streptozotocin-induced diabetic mice. Am J Physiol Heart Circ Physiol 2021 Aug 1;321(2):H259-74 *Co-first authors
Nakayama Y, Mukai N, Wang BF, Yang K, Patwari P, Kitsis RN, Yoshioka J. Txnip C247S mutation protects the heart against acute myocardial infarction. J Mol Cell Cardiol 2021 Jun;155:36-49
Nakayama Y, Yoshioka J. ADAM12 Controls a Hypertrophic Response in the Heart through the Distinct Descending Pathways. Am J Physiol Heart Circ Physiol 2020 Feb 1;318(2):H209-H211
Mukai N*, Nakayama Y*, Ishi S, Murakami T, Ogawa S, Kageyama K, Murakami S, Sanada Y, Yoshioka J** Nakajima Y**. Cold storage conditions modify microRNA expressions for platelet transfusion. PLoS One 2019 Jul 3;14(7):e0218797 *Co-first or **co-last authors
Tang H, Moon L, Yoshioka J. Body mass loss is a surrogate marker of frailty in heart failure. Int J Cardiol 2019 Feb 1;276:204-205
Yoshioka J. Ataxia-Teleangiectasia Mutate Kinase is an Autophagic Balancer at the Onset of Heart Failure. Am J Physiol Heart Circ Physiol 2018 Jul 1;315(1):H80-2