Multiscale Polyvalent Biosensing using DNA Nanotechnology & Electrochemistry 

Dr. Philip S. Lukeman 
Associate Professor 
School of Liberal Arts and Sciences 
St. John’s University, Queens, NY 

Abstract: 

We will describe here the utilization of DNA nanotechnology to construct three different electrochemical biosensor platforms that can:  

• Be used to detect a wide range of targets (DNA, proteins) by swapping independent, modular analyte binding domains and reporter domains  

• Detect 100 nm+ scale targets and discriminate intact target vs subunit binding  

• Utilize electron transfer rate as a measure of polyvalent binding